Onset & duration

Question 1

Onset & duration of Adrenaline (IV, IM, neb, IN, topical)

Answer 1

Onset: IV: 5-10 seconds; IM: 2-5 minutes; Nebulised, IN and topical: on contact with the target site │ Duration: Cardiovascular effects 5-15 minutes; mast cell membrane effects several hours

Question 2

Onset & duration of Amiodarone

Answer 2

• Onset: 5-10 minutes.
• Duration: 1-4 hours.

Question 3

Onset & duration of Aspirin

Answer 3

Onset: 30-60 minutes │ Duration: 3-5 days (antiplatelet activity)

Question 4

Onset & duration of Cefazolin

Answer 4

• Onset: 30-60 minutes.
• Duration: 6-8 hours.

Remember - onset is 30mins or over because indications are must be 30mins from ED.

Question 5

Onset & duration of Ceftriaxone

Answer 5

Onset: 30-60 minutes │ Duration: 24 hours

Question 6

Onset & duration of Clopidogrel

Answer 6

Onset: 30-60 minutes │ Duration: 3-5 days

Question 7

Onset & duration of Droperidol (IV, IM)

Answer 7

Onset: IV/IM: 5-10 minutes │ Duration: 4-6 hours

Question 8

Onset & duration of Enoxaparin

Answer 8

Onset: 10-30 minutes │ Duration: 12-24 hours

Question 9

Onset & duration of Fentanyl (IV, IM, IN, SC)

Answer 9

Onset: IV: 2-5 minutes (max effects 10-15 minutes); IN: 5-10 minutes; IM/SC: 5-10 minutes │ Duration: 30-60 minutes (respiratory effects may last several hours)

Question 10

Onset & duration of GTN (Glyceryl Trinitrate) Spray

Answer 10

Onset: 1-2 minutes │ Duration: 15-30 minutes

Question 11

Onset & duration of Glucagon

Answer 11

Onset: 5-10 minutes │ Duration: 15-60 minutes

Question 12

Onset & duration of Glucose Gel

Answer 12

Onset: 5-10 minutes │ Duration: 30-60 minutes

Question 13

Onset & duration of Heparin

Answer 13

Onset: 5-15 minutes │ Duration: 2-4 hours

Question 14

Onset & duration of Hydrocortisone

Answer 14

Onset: 10-20 minutes │ Duration: 8-12 hours

Question 15

Onset & duration of Ibuprofen

Answer 15

Onset: 30-60 minutes │ Duration: 4-6 hours

Question 16

Onset & duration of Ipratropium

Answer 16

Onset: 2-5 minutes │ Duration: 6 hours

Question 17

Onset & duration of Ketamine (IV, IM)

Answer 17

Onset: IV: 1-2 minutes; IM: 5-10 minutes; PO: 10-20 minutes │ Duration: 10-60 minutes

Question 18

Onset & duration of Levetiracetam

Answer 18

Onset: 10 minutes │ Duration: 6-8 hours

Question 19

Onset & duration of Lignocaine 1% (SC, ring)

Answer 19

Onset: 1-2 minutes (IV cannulation); 5-10 minutes (ring block) │ Duration: 30-60 minutes

Question 20

Onset & duration of Loratadine

Answer 20

Onset: 30-60 minutes │ Duration: 12-24 hours

Question 21

Onset & duration of Methoxyflurane

Answer 21

Onset: 1-2 minutes │ Duration: 2-5 minutes after cessation

Question 22

Onset & duration of Metoprolol Tartrate

Answer 22

Onset: 10-20 minutes │ Duration: 4-6 hours

Question 23

Onset & duration of Midazolam (IV, IM)

Answer 23

Onset: IV: 2-3 minutes; IM: 3-5 minutes │ Duration: 30-60 minutes (sedation may last longer in elderly)

Question 24

Onset & duration of Morphine (IV, IM, SC)

Answer 24

Onset: IV: 2-5 minutes (max effects 10-15 minutes); IM/SC: 5-10 minutes │ Duration: 30-60 minutes (respiratory effects may last several hours, especially elderly)

Question 25

Onset & duration of Naloxone (IV, IM)

Answer 25

Onset: IV: 1-2 minutes; IM: 5-10 minutes │ Duration: 30-60 minutes (often shorter than opiate duration)

Question 26

Onset & duration of Olanzapine

Answer 26

Onset: 10-20 minutes │ Duration: 12-24 hours

Question 27

Onset & duration of Ondansetron

Answer 27

Onset: IV: 2-5 minutes; IM: 5-10 minutes │ Duration: 4-8 hours

Question 28

Onset & duration of Oxytocin

Answer 28

Onset: 5-10 minutes │ Duration: 30-60 minutes

Question 29

Onset & duration of Paracetamol

Answer 29

Onset: 30-60 minutes │ Duration: 4-6 hours

Question 30

Onset & duration of Prednisone and Prednisolone

Answer 30

Onset: 30-60 minutes │ Duration: 24 hours

Question 31

Onset & duration of Salbutamol

Answer 31

Onset: 2-5 minutes │ Duration: 1-2 hours

Question 32

Onset & duration of Tenecteplase

Answer 32

Onset: 5-10 minutes │ Duration: 2-6 hours

Question 33

Onset & duration of Ticagrelor

Answer 33

Onset: 30-60 minutes │ Duration: 24 hours

Question 34

Onset & duration of Tramadol

Answer 34

Onset: 30-60 minutes │ Duration: 4-8 hours

Question 35

Onset & duration of Tranexamic Acid

Answer 35

Onset: 30-60 minutes │ Duration: 8 hours