Opioids

Question 1

Opioid - examples

Answer 1

Strong

1) oxycodone
2) morphine

Weak/mod

1) tramadol
2) codeine
3) dihydrocodeine

Question 2

Opioids - MOA

Answer 2

1) Opioids activate opioid µ receptors in the CNS
2) This reduces neuronal excitability and pain transmission
3) This reduces sympathetic nervous system activation

Question 3

Opioids - adverse effects

Answer 3

• respiratory depression
• neurological depression
• nausea/vomiting
• constipation
• itching
• withdrawal reaction - anxiety, pain, SOB
• dependence

Question 4

Opioids - caution

Answer 4

• hepatic failure
• renal impairment
• elderly
• resp failure
• biliary colic