opioids

Question 1

what is an opiate

Answer 1

derived form alkaloids of the opium poppy

Question 2

what is an opioid

Answer 2

natural and synthetic drug which mimic morphone

Question 3

what ia analgesia

Answer 3

state in which no pain is perceived despite the presence of a stimulus that would normally cause pain

Question 4

what is the MOA of opioid analgesics

Answer 4

• act by binding to receptors for endogenous opioids
• G protein of adenylyl cyclase activity
• close presynaptic voltage gated Ca++ channels
• reduces neurotransmitter release of: NE, substance P, Ach, glutamate, serotonin
• open postsynaptic K+ channels; hyper polarizes and inhibits activity

Question 5

what are the endogenous opioid peptides

Answer 5

• Enkephalins (from the head)
• Endorphins (endogenous opiate)
• Dynorphins (dynamic opiate)

Question 6

what is the precursor of enekphalins

Answer 6

proenkephalin

Question 7

what is the precursor of endorphins

Answer 7

proopiomelanocortin

Question 8

what is the precursor of dynorphins

Answer 8

prodynorphin

Question 9

where are endogenous opioid precursors found

Answer 9

at sites associated w/ pain modulation

Question 10

where do endogenous opioid peptides action occur

Answer 10

-effects occur at the spinal and supra spinal levels and at the peripheral endings of sensory nerves