1
Q
Intro
A
- controlling neurons with light
- Channelrhodopsin 2 are light sensitive proteins in the brain
- can activate neurons with light
- channelrh2 embedded into axon
- Take gene + promoter + put into virus
- To activate the protein all you need sight
- genetically modifying neurons to express light sensitive proteins
- proteins temporarily s change shape when exposed to light, altering cell beh
- Has moderate spatial resolution + very good temporal
2
Q
Optogenetics + Anxiety (Tye et al) - Methods
A
- Mice when anxious hug side of boy
- Mice explore centre of the box when less anxious- beh more erratic
- ## Light makes mouse less anxious because it effects a process in amygdala
3
Q
spatial resolution
A
- Ability to distinguish between 2 separate areas of the brain spatially
4
Q
Temporal resolution
A
- Ability to distinguish the timing of different events in the brain
