What are osteoblasts derived from?
Mesenchymal cells
What do osteoblasts produce?
- Type I collagen
Osteoblasts are affected by:
Describe osteoclasts
What do osteoclasts originate from?
Hematopoetic tissue (monocyte progenitors)
What is organic bone matrix composed of?
What is inorganic bone matrix composed of?
What type of bone makes up 80% of the skeleton?
Cortical bone
Describe cortical bone
Describe cancellous bone
- Higher rate of remodeling
What are the non-collagenous proteins in organic bone matrix?
Describe immature bone
-Not stress oriented
-Elastic in nature
(embryonic skeleton, fracture healing)
Describe pathologic bone
-Random organization
-Weak
(tumors)
Stages of fracture healing
When does primary callous occur in fracture healing?
2 weeks
Initial response of fracture healing is to:
Decrease blood flow
How does bone differ in kids?
- Cambium has increased ability for osteoblast formation
Why shouldn’t a cast be put on the first few hours following a fracture?
Inflammatory response causes bleeding/hematoma and casting it could cause compartment syndrome
What is Wolff’s Law?
Salter Harris Classification
I: transverse through physis II: through physis w/metaphysis fragment III: physis w/epiphysis fragment IV: epiphysis, physis and metaphysis V: crush injury to physis
When does blood flow begin to increase and when does it return to normal after a fracture?
- Returns to normal 3-5 months
Which piezoelectric charges stimulate osteoblasts?
Compression (electronegative)
Which piezoelectric charges stimulate osteoclasts?
Tensile (electropositive)
How are bone types classified?
FAILSS