What are the consequences of insufficient sleep
Tendency to fall asleep (MSLT)
Psychomotor vigilance testing performance decreases
- all-cause mortality
- Incresed sympathetic activity
- Increased risk of CV events
- Increased evening cortisol levels (increased cortisol supresses immune response)
- Decreased glucose tolerance
- Decreased leptin (supresses appetite)/increased gherlin (stimulates apetite)
- Altered growth hormone (muscle recovery)
- Altered immune response
With chronic partial sleep deprivation to 4-6 hours/night, all of the following are affected EXCEPT:
a. MSLT results (Multiple sleep latency test)
b. Amount of REM sleep (rapid eye movement)
c. Psychomotor vigilance scores
d. growth hormones secretory profile
e. amount of slow wave/N3 sleep
e.
Explaing the concept of the ‘flip/flop’ switch between sleep and wake
explain mutual inhibition
- Ability to remain in stable periods of sleep/wake –
- by “mutual inhibition” between wake-promoting neurons
and sleep-promoting neurons
• Transitions between states of wakefulness and
sleep –
- Relatively quick (often seconds)
- Neurological mechanism that controls these rapid
transitions akin to a “flip-flop switch”
ie: I’m just going to close my eyes for 2 secs- micro nap
What are the two processes our body use to monitor and drive the sleep/wake cycle?
explain each
homeostatic sleep dirve
circadian alerting signal- an internal biochemical system
external cues
