1
Q
Mannitol
MOA
A
It is an inert compound that passes across into the ltrate at the glomerulus and is not resorbed.
Acts in those parts of the nephron that are freely permeable to water. Increases the amount or water excreted by the kidney; has a smaller effect on sodium excretion
2
Q
Mannitol
Abs/Distrb/Elim
A
Given intravenously, not metabolised, excreted in about 30min.
3
Q
Mannitol
Clinical use
A
Cerebral oedema; reduce intracranial pressure
4
Q
Mannitol
Adverse effects
A
expansion of the extracellular fluid compartment
hyponatraemia
Pulmonary oedema
