P450

Question 1

Cytochrome p450 inducers

Answer 1

Inducers of cytochrome p450 decrease efficacy of drugs

PCBARS
	Phenytoin
	Carbamazepine
	Bbq meat
	Alcohol chronic
	Rifampicin
	St johns wort

Question 2

Cytochrome p450 inhibitors

Answer 2

Inhibitors of cytochrome p450 increase plasma concentrations of drugs resulting in toxicity

MSC ECG
	Miconazole
	Sodium valproate
	Ciprofloxacin
	Erythromycin 
	Cranberry juice
	Grapefruit juice

Question 3

Drugs metabolised by the cytochrome p450 system

Answer 3

CT W PC

Carbamazepine

Theophylline

Warfarin

Phenytoin

Contraceptive pill

Question 4

p450 inducers

Answer 4

phenytoin

carbamazepin

barbiturates - sedative

alcohol

rifampecin

stjohns wart

Question 5

p450 inhibitors

Answer 5

MSC ECG

macrolides - erythromycin

SSRI

ciprofloxacin

isoniazid

HIV protease inhibitors

amiodarone

diltiazem

verapamil

omeprazole

grapefruit juice