Paediatrics 3

Question 1

Which antigens are associated with Coeliac Disease?

Answer 1

• Class II HLA-DQ2 and -DQ8

Question 2

What is the pathophysiology behind Coeliac disease?

Answer 2

Heightened T- and B- lymphocyte responses to wheat gluten and other prolamines

Question 3

List some non-GI manifestations of Coeliac disease.

Answer 3

• Dermatitis herpetiformis
• Dental enamel defects
• Osteoporosis: Low bone mineral density

Question 4

Which antibodies are associated with Coeliac disease?

Answer 4

• Antigliadin
• Anti-endomysial
• Tissue transglutaminase

Question 5

What is the criteria for diagnosis of Coeliac disease in childhood?

Answer 5

• Characteristic histology (Marsh type III a - c)
• Positive serology
• Symptomatic response to gluten exclusion
• Resolution of antibodies

Question 6

List some risk factors for coeliac disease.

Answer 6

• Positive FHx
• Diabetics
• Short stature
• Down’s syndrome
• Thyroid disorders
• IgA deficiency