Papers

Question 1

Brown et al. Nature. 2006 (ALS)

Answer 1

General review of ALS
SOD1 153 aa protein
perhaps inclusions favourable as accumulate mSOD1
mSOD1 is pro-apoptotic, normal is anti-apoptotic

Question 2

Rowland et al. NEJM 2001 (ALS)

Answer 2

all SOD1 mutations are dominant except D90A
mSOD1 most common is A4V -> short survival
generalised treatments and therapies
General overview of ALS

Question 3

Lindvall et al. Nature 2004 (ALS)

Answer 3

Stem cell therapy in ALS
Rats regained partial function
probably due to neuroprotective mechanisms rather than new MNs
potential protective therapy