Most common bacterial infection in pregnancy
UTI
Asymptomatic bacteriuria is more common in ____ women, and these are also at higher risk for progression to upper UTI or pyelonephritis (predisposed to retention, stasis, vesicoureteral reflux, etc)
pregnant
Upper genital tract vs lower
Uterus, tubes, ovaries, pelvic peritoneum compose the upper and are all normally sterile while cervix and vagina are lower and are an infection waiting to happen
All pregnant women should be screened with a clean catch urine culture and sensitivity as well as a urine dipstick at which prenatal visit….
….first prenatal visit (12-16 weeks gestation)
Most common causative organism of UTI’s in pregnancy (1)
-E coli
Asymptomatic bacteriuria
Pregnancy disease significant bacterial colonization of the bladder without symptoms, as little as 100CFU/mL can indicate active infection depending on bacteria type***, risk of pyelonephritis is already increased in pregnancy
Risk factors of asymptomatic bacteruria (4)
Cystitis in pregnancy
Pregnancy disease symptomatic infection fo bladder with significant number of organisms >100organisms/mL with accompanying pyuria, dysuria being the most significant symptom and may be difficult to distinguish from pregnancy related complains, pelvic exam considered for all symptomatic patients
UTI in pregnancy treatment (4) and what should you NOT use and why? (3)
Pyelonephritis in pregnancy
Most common UTI complication in pregnant women most often occurring in 2nd trimester, frequently associated with septicemia, marked fetal/maternal morbidity and mortality, fetal bloodstream infection is rare so few direct fetal sequalae, but issue of hypoperfusion to placental vasculature and potential fetal cerebral hypoperfusion
Most common cause of neonatal sepsis, gold standard for diagnosis
GBS, culture with vaginal and rectal swab routinely done at 35-37 weeks gestation
Neonatal GBS presentation (4)
Treatment of maternal GBS (2)
- intrapartum prophylaxis using empiric treatment if culture results unknown
TORCHES viruses
Toxoplasmosis
Other (hep B, coxsakie, west nile, measles, HIV, zika)
Rubella
Cytomegalovirus
Herpes simplex
Erythema infectiosum (parvovirus B19 5th disease)
Syphilis
Infections developing intrauterine or during birth process
Toxoplasmosis risk factors in pregnancy (3), signs and symptoms, and treatment (1)
If mother infected with rubella in early pregnancy, __% of assing it to fetus (congeintal rubella syndrome)
90%
Congenital rubella syndrome presentation (5)
Congenital rubella syndrome is contagious for up to…
….1 year (isolation required)
CMV in pregnancy clinical presentation (2)
HSV passage from mother to child
Infected birth canal (HSV2 infection of pregnant woman), indication for c section if active visible vesicles, if mother doesn’t want to need informed consent documentation
Syphilis presentation in neonates (3)
Syphilis treatment option in pregnant women (1)
-PCN is only one
Sever disseminated varicella in the infant symptoms (3)
Severe disseminated varicella in the infant treatment options