Paternity Testing

Question 1

Obligate paternal allele

Answer 1

humans are diploid

assuming no mutation, one allele at each locus should match each parent

Question 2

Mutations

Answer 2

usually change in 1 repeat therefore do not exclude alleged father based on 1 mismatched locus

Question 3

Paternity index (PI)

Answer 3

likelihood ratio X/Y
X- probability the alleged father could transmit obligate allele
Y- probability a random man of the same race could transmit the obligate allele

Question 4

Calculations of X and Y

Answer 4

information available on mother's genotype
heterozygote vs. homozygote (X)
allele frequency (Y)

Question 5

Exclusion probability

Answer 5

combined frequency of all genotypes that would be excluded

Question 6

Kinship analysis

Answer 6

can use same principles to identify missing persons and mass disaster victims