Pathogensis of perio disease, predominant cells of EARLY lesion:
Early lesion = 4-7 days –> T-cells
pseudopocket due to inflammation
Pathogensis of perio disease , predominant cells of ESTABLISHED lesion:
Established lesion = 14-21 days –> B-cells/Plasma cells
Microulcerations which cause BOP
Does age make a difference in the progression/severity of perio disease?
Yes; better prognosis if older because % bone loss over age
leading cause of tooth loss ages >30yrs
How are periodontal tissues destroyed in periodontal disease?
- Bacterial invasion
- Immune response (cytokines & inflammatory mediators)
- Enzyme release (collagenase & protease)
- Bone and tissue destruction
- Increased plaque
- Increased inflammation
- HIGH GCF flow
- Gram NEG facultative anaerobes (which produce tissue destructive virulence factors such as LPS, leukotoxin, gingipains, collagenase, protease)
Bacterial byproducts and host immune response (cytokines, PMNs, MMPs)
What does BOP mean?
microulcerations of sulcular epithelium
What is the EARLIEST sign of gingival inflammation?
BOP
What is the situation in which we may see decreased BOP?
Smoking (vasoconstriction)
BOP in health
<10% BOP
How are the periodontal tissues destroyed in periodontal disease
Bacterial byproducts and host immune response (cytokines, PMNs, MMPs)
