1
Q
What are signs of reversible cell injury
A
ATP pumps stop working, Ca and Na/K - cell oedema.
decreased protei synthesis
plasma membrane cahnges - blebs
nuclear changes - chromatin clumping
2
Q
What are the signs of irreversible cell injury
A
Breakdown of cell membrane
Mitochondria dysfunction
Rupture of lysosymes - autolysis
pyknosis, karyorrhexis, karyolysis.
3
Q
What is in charge of the intrinsic apoptosis?
A
BAX and BAK - proapoptotic, bcl-2 and bcl-xL - antiapoptotic.
active caspases.
4
Q
What is seen in the histology of coagulative necrosis?
A
The cellular architecture is preserved but the nucleus is dissolved. stains pink/red colour
USMLE
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