What are the 5 cardinal signs of inflammation?
Rubor, DOlor, calor tumour/swelling, functio laesa (loss of function)
What is the celllular response to injury?
- margination
- chemotaxis
- pavementation
- emigration
- phagocytosis
What are the hemodynamic changes to injury?
- vasoconstriction
- vasodilation
- increased vascular permeability
- blood stasis
What are the types of acute inflammation?
- abcess
- ulcer
- fistua
- sinus
- scar
- keloid
What tissues are found with chronic inflammation?
- epitherlioid, TB (granulomatous)
- Langhan’s cells, TB
- granulomatous change
What are the tissue changes seen with chronic inflammation?
- metaplasia
- dysplasia
- anaplasia
- neoplasia
Types of necrosis?
- coagulative
- liquefactive
- caseous
- enzymatic
- fatyy
Types of degradation?
- Zenker’s
- Wallerian
What is the progressional change of the nucleus when the cell is injured?
- pyknosis
- karyorrhexis
- karyolysis
What are some immune deficiencies?
- Bruton’s agammagloulinemia
- DiGeorge Syndrome
- Severe combined immune deficiency
- Wiskott-Aldrich syndrome
- Chediak-Higaski
What are some sex linked disorders?
- Duchennes muscular dystrophy
- hemophilia
What are the autosomal chromosomal diseases?
- Down’s syndrome
- Klinefelter’s
- Turner’s
What are the autosomal dominant diseases?
- Marfans syndrome
- Ehlers-Danlos syndrome
- Osteogenesis imperfecta
- Adult polycystic disease of kidney
What are the types of autosomal recessive disorders?
- Glycogen storage
- Lysosomal storage
- Amino acid disorder
- Metabolic
- Hemopoietic
What are the glycogen storage autosomal recessive disorders?
- Von Gierke
- McArdle
- Pompe
Lysosomal Storage Disorders?
- Tay-Sachs
- Gaucher (most common)
- Niemann Pick
Amino Acid Disorders?
- Phenylketonuria
- Alkaptonuria
Metabolic Disorders?
Cystic Fibrosis
Hemopoietic disorders?
- Sickle Cell Disease
- Sickle Cell Trait
- Thalassemia
Recessive sex link disorders?
- Duchenne Muscular Dystrophy
- Becker’s Muscular Dystrophy
- Hemophilia A/B
- Lesch-Nyhan syndrome
Dominant sex-linked disorder?
- Vitamin D resistant rickets
