Pathomorphology WORDS/CLASSIFICATION

Question 1

Breslow scale:

Answer 1

Measures depth of invasion of melanoma

<0,76mm: Stage I, 99% 5-yr survival, >4mm: Stage 4, 44% 5-yr survival

Question 2

Bethesda system:

Answer 2

• ASCUS (Atypical squamous cells of undetermined significance)
• ASCH (Atypical squamous cells – cannot exlude HSIL)
• LSIL (Low grade squamous intraepithelial lesion) = CIN I
• HSIL (high grade squamous intraepithelial lesion = CIN II or III

Question 3

Cervical Intraepithelial neoplasia (CIN):

Answer 3

• CIN I: Mild cervical dysplasia involving lower 1/3rd epithelium
• CIN II: Moderate dysplasia involving lower 2/3rds
• CIN III: Severe dysplasia to CIS involving full thickness

Question 4

Multiple Endocrine Neoplasia (MEN)

Answer 4

• MEN I: Pituitary, Parathyroid, Pancreatic (ZES)
• MEN IIa: Medullary, Pheochromocytoma, Parathyroid
• MEN IIb/III: Medullary, Marfanoid habitus, Mucosal neuromas (lips/tongue), Pheochromocytoma

Question 5

Jones criteria:

Answer 5

Diagnosis of Acute Rheumatic fever, ≥ 2 Jones criteria, 1 major and 2 minor if evidence of antecedent strep A pharyngitis.

(Major: Carditis, etc; Minor: Previous RF, arthralgia, etc)

Question 6

NET:

Answer 6

well-differentiated

* CgA, Syn

Question 7

NEC:

Answer 7

poorly-differentiated, high-grade malignant

*mainly Syn, marked nuclear atypia, ++mitoses (grading based on mitotic count)

Question 8

TNM:

Answer 8

• T: Tumor size (T1-T4)
• N: Lymph node involvement (N0-N3)
• M: Extranodal metastases (liver, lung, etc) (M0-M1)