Penicillin

Question 1

Examples

Answer 1

ampicillin

amoxicillin

Question 2

Mech of Action

Answer 2

Bactericidal

interferes with cell wall by interfering with peptoglycan

allows accumulation of enzyme that destroys integrity of cell wall

Question 3

USE

Answer 3

bactericidal against pneumococcal, meningococcal, streptococcal

ampicillin has wider range of activity, includes gram - bacilli (H flu, E coli) but has increased incidence of skin rash

Question 4

metabolism/excretion

Answer 4

90% renal excretion

amoxicillin better absorbed by GI tract

Question 5

side effects

Answer 5

hypersensitivity, most allergenic of all antimicrobials

rash, fever, anaphylactic, hemolytic anemia