(400 AA) with 2 identical H chains immunoglobulin class or isotope determined by H chain?
heavy chain
(200 AA) with 2 identical L chains: Kappa or Lambda type of L chain
light chain
same AA sequence in all H and L chains of same isotype
constant region
found on H and L chains with significant variation in AA sequence in this region on H and L
variable regions
intra and inter chain
disulfide linkage
flexible/enhances affinity
hinge region