Coronary Blood Flow determined by 2 factors
- coronary vascular resistance
Delivery of Oxygen 2 factors
- oxygen content
Coronary Perfusion Pressure (eq)
CPP= DBP - LVEDP (or LAP)
normal= 60-80 mmHg
Pre-ischemic Interventions
Why give CPG
inactive heart, bloodless field, persevere muscle, lower O2 demand
Cardiac Action Potential Phases
0-Na in 1- little K out 2- Ca in (contraction) 3- K out 4- Na/K pump
3 Types of Cardioplegia
Antegrade Pressure and Flow
in line pressure= 125-150, Aortic Root= 50-100
flow= 250-400 ml/min
Retrograde Pressure and Flow
coronary sinus pressure= 30-40
flow= 200 ml/min
Direct Ostial Delivery Pressure and Flow
circuit pressure= 250-300 (high cuz small hole)
flow= 150-250 (normal CO 5-8%)
Delivery through Graft
pressure= 50 flow= 50-100 ml/min
KCl
diastolic arrest
THAM/histadine
buffer
Mannitol
osmolarity, free radical scavenger
Aspartate/glutamate/glucose
metabolic substrate
MgCl2
protects against Ca? homeostasis
CPD
lowers Ca (decrease stone heart)
Blood
oxygen carrier
what does HTK stand for in custodial HTK
histamine, tryptophan, ketogluterate
3 Phases of CPG
induction, maintenance, reperfusion