When the blood supply or perfusion is impaired
ischemia develops and can progress to necrosis,
tissue perfusion refers to
the flow of blood through arteries and capillaries delivering nutrients and oxygen to cells and removing cellular waste products.
central perfusion (mechanisms for blood delivery)
is generated by cardiac output—the amount of blood pumped by the heart each minute.
local or tissue perfusion
(actual amount of blood available to target tissues)