___________ neurons (aka somatosensory) and ____________ neurons (aka motor) are the key components of a peripheral nerve when considering regional blockade.
afferent
efferent
The peripheral nerve will have all 3 types fibers
afferent
efferent
autonomic
____________ nerves travel in the intercostal spaces and to the thoracic and abdominal compartments and are called _______________________.
Spinal
intercostal nerves
Spinal nerves travel in the intercostal spaces and to the thoracic and abdominal compartments and are called intercostal nerves.
peripheral nerve physical size (greatest to least)
Peripheral nerve >afferent and efferent fibers> fascicles (bundles of axons/ motor or dendrites/ sensory) > individual nerve fibers (aka axons)
From the spinal cord, spinal nerves are by anatomy ________________________ because they exist outside the CNS and function in their three major roles as noted below
peripheral nerves
The functional unit is the _________ with the axon being the _______________ portion.
neuron
conduction
________________ are interspersed among the axon at spaces that are not myelinated
Nodes of Ranvier
*These nodes, or axon intervals, have voltage gated sodium channels that propagate the nerve conduction and are a primary site for local anesthetic action.
Another description of the neurons is as follows
Cell body (soma)- branches of dendrites that are receivers – the axon for sending
________________ surround the axon, produce myelin that wraps the nerve and accelerates nerve conduction
schwann cells
There are three states of the sodium channel:
activated open, inactivated closed, rested closed
*Local anesthetics have the ability to block the channels in the first two states only.
3 layers of the nerve in the periphery correspond with the ________________ of the CNS
meninge layers
In the PNS, the layers are the
Epineurium, (outermost)
Perineurium, (middle)
Endoneurium (innermost)
which layer binds the substances together into bundles?
epineurium
which layer binds individual fasciles protecting the nerves with collagen and connective tissue?
perineurium
which layer consists of fluid and fibrous tissue that is produced in part by Schwann cells?
endoneurium
myelinated fibers
larger
faster
motor and sensory function
unmyelinated fibers
slower
smaller
transmit pain, temperature, and autonomic impulses
A_Beta fibers functionality includes
motor, touch, and pressure recognition
A_Alpha fibers functionality includes
motor signals and proprioception
B fibers have less _________________ and carry ______________ signals
myelination
autonomic
A_Delta fibers transmit
pain and temperature
A_Gamma fibers carry
reflexes
With local anesthetics, the ________ and more ______________ fibers are generally harder to block
larger
myelinated