Pharm

Question 1

H-1 blockers

Answer 1

First gen

• Diphenhydramine
• Dimenhydrinate
• Chlorpheniramine
• Doxylamine

Second gen

• Loratadine
• Fexofenadine
• Desloratadine

Question 2

Guaienesin

Answer 2

Expectorant

• Thins respiratory secretions
• Does not suppress cough reflex

Question 3

N-acetylcysteine

Answer 3

• Mucolytic
  
  • Liquifies mucus in chronic bronchopulmonary diseases (COPD, CF) by disrupting disulfide bunds
• Also used as an antidote to acetaminophen overdose

Question 4

Dextromethorphan

Answer 4

• Antitussive
  
  • Antagonizes NMDA glutamate receptors
• Give naloxone for overdose

Question 5

Adverse effects of pseudoephedrine and phenylephrine

Answer 5

• Hypertension
• Rebound congestion if used more than 4-6 days
• CNS stimulation/anxiety (pseudoephedrine)

Question 6

Role of pseudoephedrine and phenylephrine in respiratory tract

Answer 6

Used as nasal decongestants

Question 7

Example of an endothelin receptor antagonist

Answer 7

Bosentan

Question 8

Result on inhibition of PDE-5

Answer 8

Increase in cGMP, which leads to prolonged vasodilatory effect of NO

Question 9

When are PDE-5 drugs contraindicated?

Answer 9

When taking nitroglycerin or other nitrates, due to risk of sever hypotension

Question 10

Side effects of prostacyclin analogs

Answer 10

Flushing

Jaw pain

Question 11

Examples of prostacylin analogs

Answer 11

Epoprostenol

iloprost

Question 12

Toxicity of zileuton

Answer 12

Hepatotoxic

Question 13

When is omalizumab used?

Answer 13

In allergic asthma, with increased IgE levels resistant to inhaled steroids and long-acting B2-agonists