Pharm 9 - Cholinergics

Question 1

Degrades synaptobrevin and thus prevents synaptic vesicle fusion with the axon terminal membrane

Answer 1

• Botulinum Toxin

- Produced by C. Botulinum

Question 2

Inhibit acetylcholinesterase (AChE) by binding to the enzyme’s active site. (5)

Answer 2

• Edrophonium
• Neostigmine
• Pyridostigmine
• Ambenonium
• Physostigmine

Question 3

Use for Focal Dystonias, Torticollis, Achalasia, Strabismus, Blepharospasm, Pain Syndromes, Wrinkles, and Hyperhidrosis

Answer 3

• Botulinum Toxin (BoTox)

Question 4

Use for Myasthenia Gravis, Eaton-Lambert Syndrome or other muscles weakness disorders (4)

Answer 4

• Edrophonium
• Neostigmine
• Pyridostigmine
• Ambenonium

Question 5

Use for Reversal of anticholinergic toxicity or induced surgical paralysis

Answer 5

• Physostigmine

Question 6

Has direct cholinergic agonist effect at Nm receptors

Answer 6

• Neostigmine

Question 7

Topical application of (blank, blank) to the cornea of the eye decreases intraocular pressure by facilitating the outflow of aqueous humor

Answer 7

• Cholinesterase Inhibitors

Question 8

AChE Inhibitor encountered as a toxin, used as an insecticide

Answer 8

• Diisopropyl Fluorophosphate

Question 9

AChE Inhibitor Used for Alzheimer’s Disease and Dementia

Answer 9

• Tacrine, Donepezil, and Rivastigmine

Question 10

Stimulate Muscarinic Receptor Activity (Muscarinic Receptor Agonists)

Answer 10

• Methacholine
• Carbachol
• Bethanechol
• Cevimeline
• Pilocarpine

Question 11

Used to Diagnose Asthma

Answer 11

Methacholine

Question 12

Muscarinic Receptor Agonist Used for Glaucoma

Answer 12

• Carbachol

Question 13

Muscarinic Receptor Agonist Used for Urinary Tract Motility

Answer 13

• Bethanechol

Question 14

Muscarinic Receptor Agonists Used for Xerostomia in Sjogren’s Syndrome

Answer 14

• Cevimeline and Pilocarpine

Question 15

Adverse Effects Include Dyspnea, Lightheadedness, pruritus and throat irritation

Answer 15

• Methacholine

Question 16

Stimulate opening of nicotinic ACh receptor channel and produce depolarization of the cell membrane (creates a depolarizing blockade)

Answer 16

• Succinylcholine

Question 17

Used to induce neuromuscular blockade in surgery and for intubation

Answer 17

• Succinylcholine

Question 18

Adverse Effects Include Muscle Rigidity, myalgia, and raised intraocular pressure

Answer 18

• Succinylcholine

Question 19

Muscarinic Receptor Antagonist used for Anticholinesterase Overdose, Bradycardia, Premedication for anesthetic, and Antidote to Mushroom Poisoning

Answer 19

• Atropine

Question 20

Side Effects Include Raised Intraocular pressure, tachycardia, constipation, xerostomia, and blurred vision

Answer 20

• Atropine

Question 21

Muscarinic Receptor Antagonist used for Motion Sickness, Nausea, and Vomiting delivered via transdermal patch

Answer 21

• Scopolamine

Question 22

Muscarinic Receptor Antagonist Used for Peptic Ulcer Disease (PUD) and induced bradycardia

Answer 22

• Pirenzepine, Methscopolamine, and Glycopyrrolate

Question 23

Muscarinic Receptor Antagonist Used for Asthma and COPD

Answer 23

• Ipratropium and Tiotropium

Question 24

Muscarinic Receptor Antagonist Used for Overactive Bladder and Urge Incontinence

Answer 24

• Oxybutynin, Propantheline, and Terodiline

Question 25

Nicotinic Receptor Antagonists, prevent endogenous ACh binding and subsequent muscle cell depolarization (nondepolarizing blockade)

Answer 25

- Pancuronium, Tubucurarine, Vecuronium | - Trimethaphan and Mecamylamine

Question 26

MOA of Edrophonium, Neostigmine, Pyridostigmine, Ambenonium and Physostigmine

Answer 26

Acetylcholinesterase Inhibitors

Question 27

MOA of Pancuronium, Tubucurarine, Vecuronium, Trimethaphan and Mecamylamine

Answer 27

Nicotinic Receptor Antagonists

Question 28

MOA of Oxybutynin, Propantheline, and Terodiline

Answer 28

Muscarinic Receptor Antagonists

Question 29

MOA of Ipratropium and Tiotropium

Answer 29

Muscarinic Receptor Antagonists

Question 30

Pirenzepine, Methscopolamine, and Glycopyrrolate

Answer 30

Muscarinic Receptor Antagonists

Question 31

MOA of Tacrine, Donepezil, and Rivastigmine

Answer 31

AChE Inhibitors