Aminoglycosides
"GNATS" Gentamicin Neomycin Amikacin Tobramycin Streptomycin
Aminoglycosides - Adverse effects
NEPHROTOXICITY
Neuromuscular blockade (NO in MG)
OTOTOXICITY (specially with loop diuretics)
Teratogenicity
Aminoglycosides - Mechanism of resistance
Bacterial transferase enzymes inactivate the drug by acetylation, phosphorylation or adenylation.
Aminoglycosides - Mechanism of action
Bactericidal
Irreversible inhibition of initiation complex by binding of the 30S subunit.
Inducers
MOdafinil CHRONIC ALCOHOL use St. John Wort PHENytoin PHENobarbital NEvirapine Rifampin GRIseofulvin CARBamazepine
Inhibitors
Sodium valproate Isoniazid Cimetidine Ketoconazole Fluconazole Acute alcohol use Chloramphenicol Erythromycin/Clarythromycin Sulfonamides Ciprofloxacin Omeprazole Metronidazole Amiodarone Ritonavir Grapefruit Juice
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Substrates
Anti-epileptics
Theophyline
Warfarin
OCP’s