❤️ Pharm- ARBs

Question 1

Candesartan
Olmesartan
Eprosartan
Telmisartan
Irbesartan
Valsartan
Losartan

Answer 1

ARB’s

-“sartan”

Question 2

ARBS

Angiotensin 2 receptor blockers/ antagonists

Answer 2

MOA: block the effects of angiotensin 2

• AT1 and AT2 receptor binding is blocked
• vasodilation
• ⬇️ aldosterone
• ⬇️ renin release

Question 3

Side effects

Answer 3

• hyperkalemia
• NO cough
• hypotension
• dizziness
• renal dysfunction

Question 4

Inx/risk

Answer 4

Similiar to ace inhibitors

• NSAIDs
• K supplements

Question 5

How do ARBs lower BP?

Answer 5

By blocking the effects of angiotensin 2.

• vasodilation
• lower aldosterone
• block renin release

Question 6

Neprilysin inhibitor

-Enteresto ( sacubitril)

Answer 6

• only co-packaged with Valsartan (ARB)
• reduces vasoconstriction and increases vasodilation= ⬇️ BP
• by blocking the conversion of ant1 to ant2
• given with Valsartan
• hypotension
• impaired renal fxn
• hyperkalemia
• angioedema

Question 7

Arbs use what kind of dosing?

Answer 7

• target dosing*