Pharm equations

Question 1

How to determine Ke (elimination constant)?

Answer 1

Ke = Cl (clearance) / Vd

Question 2

How to determine Volume of distribution?

Answer 2

Vd = total drug / plasma concentration (C0)

Question 3

What are the two equations for determining half life t1/2?

Answer 3

t1/2 = 0.693 / Ke (elimination constant) 
t1/2 = 0.693 (Vd / Cl)

Question 4

How can you determine steady state concentration (Css)?

Answer 4

Css = Kin (drug input) / Cl (clearance)

Question 5

Maintenance dose =

Answer 5

M. D. = (dosing rate X interval) / f

Question 6

Loading dose =

Answer 6

L. D. = (Css x Vd) / f

Question 7

Bioavailability (f) =

Answer 7

f = AUC oral / AUC IV