Clinical use of Penicillin G, V?
Bactericidal or bacteriostatic?
AE? (general)
- g+ (S. pna, S. pyo, Actinomyces), g- cocci (N. meningitidis), spirochetes (Treponema)
- bactericidal
- hypersensitivity reactions, direct coombs + hemolytic anemia
Penicillinase-sensitive penicillins? (2)
Which has greater oral bioavailability?
Clinical use?
- amoxicillin (better oral bioavailability)
- ampicillin
- H. influ, H. pylori, E. coli, Listeria, Proteus, Salmonella, Shigella, enterococci
Penicillinase-resistant penicillins (3)?
How?
Clinical use?
- Nafcillin, dicloxacillin, oxacillin
- bulky R group blocks access of beta lactamase to beta lactam ring
- S. aureus (MSSA)
Anti-pseudomonal penicillins? (2)
Clinical use?
Piperacillin, ticarcillin
Pseudomonas, g- rods, use with beta lactamase inhibitors
beta lactamse inhibitors (4)
clavulanic acid
avibactam
sulbactam
tazobactam
what drugs are focal to massive hepatic necrosis?
HAVAc
- Halothane
- Amanita phalloides (death cap mushroom)
- Valproic acid
- Acetaminophen
Drugs causing pancreatitis?
Drugs Causing A Violent Abdominal Distress
- Didanosine
- Corticosteroids
- Alcohol
- Valproic acid
- Azathioprine
- Diuretics (furosemide, HCTZ)
Drugs causing agranulocytosis?
Can Cause Pretty Major Collapse of Granulocytes
- Clozapine
- Carbamazepine
- Propylthiouracil
- Methimazole
- Colchicine
- Ganciclovir
Drugs that can cause aplastic anemia?
Can’t Make New Blood Cells Properly
- Carbamazepine
- Methimazole
- NSAIDs
- Benzene
- Chloramphenicol
- Propylthiouracil
Drug reaction with eosinophilia and systemic symptoms (DRESS) delayed HS rxn
allopurinol, anticonvulsants, abxs, sulfa drugs
Hemolysis in G6PD deficiency can be brought on by what drugs?
hemolysis IS D PAIN
- Isoniazid
- Sulfonamides
- Dapsone
- Primaquine
- Aspirin
- Ibuprofen
- Nitrofurantoin
Drugs causing megaloblastic anemia?
Hydroxyurea, Phenytoin, Methotrexate, Sulfa drugs
drugs precipitating hyperuricemia and/or gout
Painful Tophi and Feet Need Care
- Pyrazinamide
- Thiazides
- Furosemide
- Niacin
- Cyclosporine
What drugs can cause SLE like ssx?
Sulfa drugs, Hydralazine, Isoniazid, Procainamide, Phenytoin, Etanercept
What drugs have seizures as a major AE?
with seizures I BITE my tongue
- Isoniazid (B6 deficiency)
- Buproprion
- Imipenem/cilastatin
- Tramadol
- Enflurane
What drugs cause pulmonary fibrosis?
My Nose Cannot Breathe Bad Air
- Methotrexate
- Nitrofurantoin
- Carmustine
- Bleomycin
- Bulsulfan
- Amiodarone
Drugs that cause Disulfram like reactions
Sorry Pals, Can’t Go Mingle
- Sulfonylureas first gen
- Procarbazine
- Cephalosporins (some)
- Griseofulvin
- Metronidazole
Inducers of Cytochrome P450
Chronic alcoholics Steal Phen Phen and Never Refuse Greasy Carbs
- Chronic alcohol use
- St. Johns wart
- Phenytoin
- Phenobarbital
- Nevirapine
- Rifampin
- Griseofulvin
- Carbamazepine
Substrates of cytochrome P450
Always Think When Outdoors
- Antiepileptics
- Theophylline
- Warfarin
- OCPs
Inhibitors of cytochrome P450
SICKFACES.COM
- Sodium valproate
- Isoniazid
- Cimetidine
- Ketoconazole
- Fluconazole
- Acute alcohol abuse
- Chloramphenicol
- Erythromyocin (macrolides)
- Sulfonamides
- Ciprofloxacin
- Omeprazole
- Metronidazole
Sulfa drugs include
Scary Sulfa Pharm FACTS
- Sulfonamide abx
- Sulfasalazine
- Probenecid
- Furosemide
- Acetazolamide
- Celecoxib
- Thiazides
- Sulfonylureas
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