Endocrine/GI System > Pharm: Thyroid > Flashcards

Pharm: Thyroid Flashcards

(24 cards)

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1
Q

synthetic thyroid hormone drugs

A

levothyroxine, liothyronine

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2
Q

levothyroxine mechanism of action

A

synthetic T4

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3
Q

levothyroxine clinical uses

A

hypothyroidism, myxedema coma, weight loss

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4
Q

levothyroxine side effects

A

toxicity (overdose) –> hyperthyroidism

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5
Q

liothyronine mechanism of action

A

synthetic T3

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6
Q

liothyronine clinical uses

A

hypothyroidism, myxedema coma, weight loss

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7
Q

DOCs for hypothyroidism

A

levothyroxine, liothyronine

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8
Q

thioamides

A

methimazole, propylthiouracil (PTU)

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9
Q

methimazole mechanism of action

A

inhibits thyroid peroxidase and iodide organification

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10
Q

methimazole and propylthiouracil mechanism of action

A

inhibits thyroid peroxidase and iodide organification, inhibits converstion of T4 to T3

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11
Q

methimazole clinical use

A

hyperthyroidism (DOC in pregnant pts after first trimester)

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12
Q

propylthiouracil clinical use

A

hyperthyroidism (DOC in first trimester pregnant pts)

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13
Q

methimazole side effects

A

teratogen*, rash, agranulocytosis, aplastic anemia

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14
Q

propylthiouracil side effects

A

severe hepatitis*, rash, agranulocytosis, aplastic anemia

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15
Q

beta-blocker

A

propranolol

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16
Q

propranolol mechanism of action

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A

inhibits conversion of T4 to T3

17
Q

propranolol clinical uses

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A

hyperthyroidism, thyroid storm

18
Q

corticosteroid drugs

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A

glucocorticoids

19
Q

glucocorticoids mechanism of action

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A

modulate conversion of T4 to T3

20
Q

glucocorticoids clinical uses

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A

thyroid storm, opthalmopathy associated with hyperthyroidism

21
Q

drugs used for hypothyroidism

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A

levothyroxine, liothyronine

22
Q

drugs used for hyperthyroidism

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A

methimazole (1st DOC), propylthiouracil, propranolol, glucocorticoids

23
Q

drugs used for thyroid storm

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A

propranolol (1st DOC), glucocorticoids

24
Q

increased dose of levothyroxine is required in ____

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A

pregnancy (b/c TBG is high in pregnant = less free T4)

Endocrine/GI System
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