Pharmacogenesis

Question 1

What is L41 mutation

Answer 1

The GRK5 L41 mutation causes the GRK5 to internalize the GPCR protein more rapidly.

Question 2

What happens when these patients take beta blockers

Answer 2

There is not as much of a difference as patients with the normal allele in the heart simulation

People with L41 have “built in” beta blocker

Question 3

In which ethnicity is this mutation common

Answer 3

African American