Pharmacology Chapter 12 - Basic Principles of Neuropharmacology

Question 1

3 Major steps in neuron action…

Answer 1

1. Conduction of action potential.
2. Release of neurotransmitter from axon.
3. Binding of transmitter molecules to receptors on post-synaptic cell.

Question 2

Most neuropharmacologic agents act at…

Answer 2

synapse transmission level.

Question 3

5 Steps in Synaptic Transmission -

Answer 3

1. Synthesis of transmitter molecules.
2. Storage of transmitter molecules in the vesicles.
3. Release of transmitter molecules by action potential into synaptic gao.
4. Receptor binding (reversible.)
5. Termination by release of transmitter form receptor and synaptic gap (by reuptake, enzymatic degradation, and diffusion.)

Question 4

Drugs can….(2)

Answer 4

Enhance receptor activation and reduce receptor activation.

Question 5

Transmitter synthesis -

Answer 5

increase, decrease, cause synthesis of transmitter type that is more effective than natural transmitter.

Question 6

Interference with transmitter storage -

Answer 6

can decrease storage or decrease storage in vesicles.

Question 7

Transmitter release -

Answer 7

promote or inhibit release. Like, amphetamines increase transmitter release., and Botulinus toxin inhibits transmitter release.

Question 8

Receptor binding -

Answer 8

enhancement of binding (agonists) / synergism of action - both bind to receptor. 
Blocking binding (antagonists) - blockage of receptor or lowering of affinity of receptor for transmitter.

Question 9

Termination of transmitter action -

Answer 9

blockade of transmitter reuptake, inhibition of transmitter degradation.

Question 10

The greater the number of receptors, the __ the chances of obtaining ___ drug effects.

Answer 10

greater/selective.