Pharmakokinetics

Question 1

lipids diffuses easily via:

Answer 1

passive diffusion

Question 2

Passve diffusion determined by what 2 factors

Answer 2

partition coefficient

concentration gradient

Question 3

Weak acids: form that will passively diffuse

Answer 3

HA form bc not charged

Question 4

When hydrogen conc is high, what form of weak acid predominates

Answer 4

HA

Question 5

[HA]/ [A-] determined by what two factors

Answer 5

pH of environment and pKa of drug

Question 6

pKa of molecule here has pH where we are 50% protonated, 50% deprotonated

Answer 6

Inflection point

Question 7

When can a weak base pass the membrane

Answer 7

when pH is high and there is a low conc of H+

Question 8

in the concept of ion trapping,
acidic drugs get trapped:
basic drugs get trapped:

Answer 8

more basic side, higher pH

more acidic side, lower pH