Which are mechanisms of crossing cell membranes
Diffusion directly through lipid
Diffusion through aqueous pores
With a carrier molecule
Pinocytosis
All of the above
Loopholes drugs can be described as
1. Unionised,lipophobic, hydrophilic., polar
2. Ionised lipophobic hydrophilic, polar
3 unionised lipophilic hydrophobic nonpolar
4. Unionised lipophilic hydrophobic polar
3 unionised lipophillic hydrophobic non polar
A weak acid drug will easily be absorbed in an environment with ph9.0
False - alkali environment like with like favours absorption
A weak acid drug will not be easily absorbed in an environment with ph9 -why??
Drug is mostly unionised form
Drug is mostly ionised form
Ionised form ( not cross membranes easily)
Environmental ph can have clinically relevant effects
True
Absorption is important for all routes of administration
False
Most drug absorption occurs in the
Small intestine
Plasma proteins represent drug targets
False
Although not drug targets, plasma protein levels can effect drug activity
True
Drug distribution is dependant at least partially on the lipid solubility of the drug
True
Drugs with limited plasma protein binding and high lipid solubility will have a
High volume of distribution
Low volume of distribution
High (not being held, it’s free and can move across membranes)
