Physiology Flashcards by Clare Shanks

Q

3 molecules that regulate calcium in the blood

A

PTH
Calcitonin
Vit D (synthesised in kidneys)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Vit D synthesis steps

A

7-dehydrocholesterol converted to D3 with UV
Liver = D3 –> 25HD
Kidney = converted to calcitriol
Calcitriol stimulated intestinal epithelial cells to increase calbindin-D proteins

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

how does PTH raise blood calcium levels

A

Increase bone resorption by binding to osteoblasts to express RANKL = increases osteoclasts
Increase renal reabsoprtion Ca
Increasws synthesis of calcitriol

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Calcitonin and calcium regulation

A

Ca rises above normal range = stim thyroid gland to secrete calcitonin
Decreases calcium levels by ingibiting osteoclasts

How well did you know this?

1

Not at all

2

3

4

5

Perfectly