Pk-PD

Question 1

conc-dependent

Answer 1

aminoglycosides
fluroquinolones
daptomycin
metronidazole (against anaerobes)

Question 2

conc-independent

Answer 2

b-lactams
glycopeptides
macrolides
clindamycin
tetracyclines
linezolid

Question 3

most correlated with Cmax/MIC

Answer 3

amionglycosides

fluroquinolones

Question 4

most correlated with AUC/MIC

Answer 4

quinolones
aminoglycosides
glycopeptides

Question 5

most corrlated with T>MIC

Answer 5

b-lactams
glycopeptides
macrolides
clindamycin
tetracyclines
linezolid

Question 6

dosing paradigm

Answer 6

b-lactams: higher frequency, prolonged infusions
vancomycin (AUC/MIC): flexible
fluoroquinolones (both): flexible, high dose
aminoglycosides (both): high dose, low frequency

gram negative only
enterococcal endocarditis exception (longer dose, high freq)

Question 7

PK-PD indices

b-lactams
aminoglycosides
quinolones (conc)
daptomycin (conc)
tetracyclines  (time)
glucopeptides (time)
macrolides  (time)

Answer 7

b-lactam: Time above MIC
amino: Cmax/MIX

quinolones
daptomycin 
tetracyclines
glucopeptides
macrolides:

AUC/MIC
then look at second layer