pkpd module 4 Flashcards by Stephanie Flint

Q

if limited solubility is saturated

A

dec F

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Q

if active absorption is saturated

A

dec F

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Q

if efflux transport is saturated

A

inc F

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Q

if p-gp induction is saturated

A

dec F

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Q

if tubular secretion is saturated

A

dec renal CL

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Q

if active tubular reabsorption is saturated

A

inc renal CL

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Q

if biliary secretion saturated

A

dec hepatic CL

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Q

if capacity limited matabolism is saturated

A

dec CL

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Q

if saturable first-pass metabolism saturated

A

inc F

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Q

if autoinduction saturated

A

inc CL

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Q

if mechanism-based autoinduction saturated

A

dec CL

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Q

if saturable plasma protein binding saturated

A

inc V, change CL depends on E

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Q

if saturable tissue binding saturated

A

dec V

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Q

if half life changes, think change in

A

CL

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Q

if V or Cmax changes, think change in

A

F

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