Pleuromutilins

Question 1

Mode of action

Answer 1

50S protein synthesis- bacteriostatic

Question 2

Cross resistance with:

Answer 2

macrolides and phenicols

Question 3

Pharmacokinetics

Answer 3

Absortion: Excellent oral
Distribution: Excellent
Metabolism: Liver- CYP450 inhibition!! THINK when use other medicines. incr toxicity
Excretion: bile and urine

Question 4

Toxicity

Answer 4

Low, but can maybe cause vulvar edema from urine, skin erythema.

Question 5

Spectrum:

Answer 5

Gram+, fastidious, Brachyspira, Lawsonia (intracellular), Mycoplasma (no cell wall)

Question 6

Indication:

Answer 6

Swine dysentery, proliferative enteropathy, mycoplasmosis, respiratory tract inf.- pig and poultry

Question 7

Drugs:

Answer 7

Tiamulin- inj and oral
Valnermulin- oral
ONLY to food producing animals!