pMDIs

Question 1

what is pMDI

Answer 1

pressurised aerosols with multiple doses
deep lung deposition needed for asthma treatment
usually suspension can be solution

Question 2

describe formulation of pMDI

Answer 2

propellant - liquified gas
surfactants - oleic acid
co solvents - ethanol - better solubility
drug - 1-10um

Question 3

pMDI solution formulations

Answer 3

• drug soluble in HFA
• increase lung deposition
• droplets evaporate - fine particles left
• more reaches lung - decrease dose needed

Question 4

aerosol containers

Answer 4

glass
plastic
tin plate
aluminium

Question 5

fillin pMDIs

Answer 5

cold filling

• contents/propellant - cooled due to volatile nature
• drugs and excipients mixed with propellant

pressure filling

• kept under increase pressure
• deformation of can

Question 6

cascade impactor

Answer 6

• particles send through stack stage
• each stage has decreased orifices size
• where particles are caught - determine size = where in lung they land