1
Q
mutations present in >95% of cases and detectable in peripheral blood leukocytes…
A
Jak2 mutations
2
Q
Bone marrow smear morphology and characteristics
A
–Increase in megakaryocytes AND erythroid precursors…(some overla in pathogenesis of P. vera and ET, but not understood)
–Hypercellular marrow
(b/c meg and erythroid hyperplasia)
3
Q
Clinical Presentation
A
Thrombosis!!! hypertension stroke MI (But Remember: Increased RBC's can also be due to lung disease!)
4
Q
Prognosis
A
> 10-yr. survival is common
can progress to myelofibrosis, MDS, acute leukemia
5
Q
Immunophenotype
A
No known features
Hematology
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