Population Genetics

Question 1

cystic fibrosis has a heterozygous resistance to

Answer 1

typhoid fever

Question 2

hemochromatosis has a heterozygote advantage in

Answer 2

an iron-poor environment

Question 3

Glucose 6P dehydrogenase deficiency and the resulting hemolytic anemia has a heterozygote resistance to

Answer 3

malaria

Question 4

sickle cell disease has a heterozygous resistance to

Answer 4

malaria

Question 5

Siblings share what % of their genes

Answer 5

1/2 (50%)

Question 6

1st cousins share what percentage of their genes?

Answer 6

1/8

Question 7

2nd cousins share what percentage of their genes?

Answer 7

1/32

Question 8

Hardy-Weinberg equilibrium

Answer 8

• p(squared) + 2pq + q(squared) = 1
• p and q are the allele frequencies at a locus
• allows calculations of carrier frequency and prevalence of genetic disease
• For AR diseases:
• p (squared) = homozygous normal
• 2pq = heterozygous carrier
• q (squared) = homoqygous affected
• when calculating allele frequency, remember that p + q = 1