Practical question 2

Question 1

Single i.v log graph

Answer 1

X axis = time
Y axis = ln[C]

Gradient = -ke
Y intercept = Ln[C0]

Question 2

Half life

for single iv

Answer 2

t0.5 = 0.693/ke

Question 3

Working out clearance

single iv

Answer 3

AUC = C0/ke

Clearance = dose/AUC

Question 4

Volume of distribution

single iv

Answer 4

Vd = clearance/Ke

Question 5

Assumptions for single iv injection single compartment

Answer 5

Well mixed so no distribution
1st order elimination
Drug equally distributed at same conc as plasma