What is prematurity?
Birth before 37+0
What is extreme prematurity?
<28 weeks
What is severe prematurity?
28-31+6
What is moderate prematurity?
32-33+6
What is late pre-term?
34-36+6
What is the age of viability?
24 weeks, but if 23+ and 400g, showing signs of life then resus often attempted
What is the incidence?
more than 52,000 in 2012
What is the major long term concequence of prematurity?
neurodevelopmental delay
What are the 4 types of risk factors for Preterm labour and PPROM?
what are the 9 behavioural and environmental risk factors of pre term labour and PPROM?
What demographic are more likely to go into preterm labour and PPROM? 4
What medical risk factors can cause preterm labour and PPROM? 7
Infection (Uti’s)
Diabetes - altered insulin requirement affects placental efficiency
Renal disease
Cardiovascular disease
Hypertension (delivery is only way to reduce)
Antiphospholipid syndrome - can lead to iugr
Psychiatric disorders
What are the reproductive risk factors? 9
What are the 5 ways to prevent pre-term labour?
How do we diagnose preterm labour?
- fetal fibronectin
What 4 drugs are given in pre-term labour?
Antenatal corticosteroids - beta/dexamethasone
Nifidipine
Magnesium sulfate
Antibiotics
What are corticosteroids for?
26-34/40, makes baby stressed so they produce surfactant to keep lungs inflated
What is nifidipine for?
calcium channel blockers- stops the uterus contracting
What is magnesium sulfate for?
comes from pre-eclampsia as reduces maternal fits- helps baby’s neurodevelopment
How do they monitor the fetus in pre-term labour?
intermittent monitoring because if CTG at 25/40 and abnormal- not going to go to emcs
Do they do delayed cord clamping in pre-term labour?
30 seconds, no more than 3 minutes
What is fetal fibronectin?
Extracellular matric glycoprotein localized at the maternal-fetal interface of the amniotic membrane- between chorion and decidua. If present in cx fluid up to 22/40 then released as indicator of possible delivery.
What medical options are there for tocolysis?
Does tocolysis improve outcomes?
there is no evidence to suggest this