Primary biliary cholangitis

Question 1

Cause

Answer 1

Destruction of small intrahepatic bile ducts due to anti-microbial antibodies

Question 2

What is cholestasis

Answer 2

Flow of bile from liver to bile ducts is obstructed

Question 3

Consequences of cholestasis

Answer 3

Inflammation to hepatocytes, leading to fibrosis, cirrohosis and liver fialure

Question 4

Symptoms of PBC

Answer 4

Pruritis
Jaundice
RUQ
Autonomic dysfunction e.g. postural dizziness, loss of concentration, dry eyes and dry mouth (sjogren's)
Symptoms of cirrhosis/liver failure

Question 5

Rx

Answer 5

PMH of autoimmune disease
FH of autoimmune disease
Smoking
Hypercholestrolemia
UTIs

Question 6

What is a key risk factor and for which population?

Answer 6

UTIs

Caucasians

Question 7

Epidemiology of PBC

Answer 7

Middle aged young women (UTI also common in this group)