PRINCIPLES

Question 1

Principle 1

Answer 1

susceptibility depends on genes and adverse environmental factors

Question 2

Principle 2

Answer 2

susceptibility varies with developmental stage at the time of exposure

Question 3

Principle 3

Answer 3

agents act on developing cells and tissues to initiate sequences of abnormal developmental events

Question 4

Principle 4

Answer 4

the access of adverse influences to developing tissues depends on the
nature of the influence

Question 5

Principle 5

Answer 5

The four manifestations of deviant development are death,
malformation, growth retardation, and functional deficit

Question 6

Principle 6

Answer 6

The frequency and severity of teratogenic effects is
proportional to (a) timing of exposure (principle II), (b) dose,
and (c) duration of exposure