Tocolysis: is the ???
inhibition of uterine contraction
Indication for tocolysis
To allow a __________ for ________
Uterine ____________ (from excess oxytocin)
To perform _________________
Management of ____________
Aspart of post-operative management for _____________
course of steroid ; fetal lung maturation
hyperstimulaion; External cephalic version
dysmenorrhea; cervical cerclage
Classification of tocolytics
List 6 classes
Beta-mimetics
Calcium channel blockers
Oxytocin antagonist
Magnesium sulphate (MgSO4)
Prostaglandin synthase inhibitors
Nitrates
Classification of tocolytics
Beta-mimetics: ritodrine, _________,____________
Calcium channel blockers: _________
Oxytocin antagonist:__________
Magnesium sulphate (MgSO4)
Prostaglandin synthase inhibitors: __________
Nitrates: __________________
terbutaline, salbutamol
nifedipine; atosiban
indomethacin
glyceryl trinitrate
AZT: __________
NVP: __________
3TC: __________
EFV: __________
Zidovudine
Nevirapine ; Lamivudine
Efavirenz
Kleihauer-Betke test
- A test of maternal blood to determine the proportion of ________ present; based on the fact that ?????????????
fetal cells
fetal cells resist denaturation by alcohol or acid
Kleihauer-Betke test
gives an estimate of volume of ____________________ and amount of __________________________ required
feto-maternal transfusion
extra anti-D immunoglobulin (e.g. RhoGAM)
Anti-D level : Outcome
HDFN unlikely
Moderate risk of HDFN
High risk of hydrops fetalis< 4 IU/mL
4-15 IU/mL
> 15 IU/mL
Cervical insufficiency formerly known as cervical incompetence: is the inability of the uterine cervix to _______________ due to a _________ or ___________ detect
sustain pregnancy to term
functional ; structural
Cervical insufficiency
It accounts for 20-25% of __________ trimester miscarriage as well as 10% of preterm deliveries
second
gestational ages at which miscarriage occurs in cervical insufficiency _____ease progressively as opposed to that due to uterine structure anomaly where gestational ages ______ease
progressively
decr
incr
Clinical presentation of Cervical Insufficiency
• Recurrent spontaneous _____-trimester abortion that is
preceded by:
- Pelvic _________ (due to descent of uterine content)
-________ or __________ vaginal discharge
-________ vaginal bleeding or spotting
- Pain_____ cervical dilatation, rupture of membrane, and expulsion of uterine content
mid; heaviness
Watery or mucoid
Painless; painless
In cervical insufficiency
Hysterosalpingography: shows a _______ or ______ shaped defect, indicating the __________ ______________ and widened isthmus
funnel ; beak
dilated internal os
Contraindications to HSG
P
R
I
M
E
Pregnancy
Reaction to Dye
Infections
Menses
Endometriosis
Complications of HSG
List 7
Allergy to die
Haemorrhage
Pain
Intravasation of Dye
Perforation of Uterus
Pulmonary embolism
Miscellaneous (VOTERS)
Complications of HSG
VOTERS
Vasovagal attacks
Ovarian abscess
Thyroid function change
Endometriosis
Rupture of pyosalpinx
Sepsis
Treatment modalities of cervical insufficiency : surgery (_________ ), medical, use of ____________ , and ___________
cerclage
pessaries
bed rest
Cervical cerclage is a minor surgical procedure in which the ___________________ is ______________
cervical opening is stitched close
Cerclage is placed between __________ weeks (when early abortion due to other factors would have occurred) and removed at _______ weeks (if indication for early removal does not arise.
14-16
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