Prostate pathology

Question 1

Acute bacterial prostatitis is most often secondary to this

Answer 1

UTI

Question 2

In acute bacterial prostatitis, edema may cause this

Answer 2

Outlet obstruction

Question 3

Chronic bacterial prostatitis is most often with a history of this

Answer 3

Recurrent UTI

(coliforms, E. coli)

Question 4

A male patient with low back pain, and suprapubic discomfort and fullness, may have this condition

Answer 4

Chronic bacterial prostatitis

Question 5

Chronic bacterial prostatitis clinically presents as this

Answer 5

Low back pain
Suprapubic discomfort, fullness

Question 6

Chronic abacterial prostatitis is part of this

Answer 6

Chronic pelvic pain syndrome

Question 7

Chronic abacterial prostatitis may have these in secretions

Answer 7

Leukocytes

Question 8

What do cultures show in Chronic abacterial prostatitis?

Answer 8

Negative

Question 9

This is the most common cause of Granulomatous prostatitis

Answer 9

BCG

Question 10

The most common cause of this condition is BCG
Also seen with foreign body reaction

Answer 10

Granulomatous prostatitis

Question 11

Is Benign prostatic hyperplasia pre-malignant?

Answer 11

NO

Question 12

Benign prostatic hyperplasia tends to involve these zones

Answer 12

Central and periurethral zones

Question 13

Benign prostatic hyperplasia occurs in androgen sensitive tissues, so may be treated with these

Answer 13

5a reductase inhibitors

Question 14

Histology in Benign prostatic hyperplasia shows this

Answer 14

Benign glands

(two cell layers, no nucleoli)

Question 15

Benign prostatic hyperplasia produces these 4 clinical symptoms

Answer 15

Outflow obstruction
Slow flow
Urine retention
Firm, enlarged, smooth non-tender prostate

Question 16

This condition produces outflow obstruction, slow flow, urine retention
Firm, enlarged, smooth, non-tender prostate

Answer 16

Benign prostatic hyperplasia

Question 17

Benign prostatic hyperplasia can cause this, which results in possible UTI, hydronephrosis, nocturia, and frequency

Answer 17

Urine retention

Question 18

Does Benign prostatic hyperplasia cause the prostate to be tender?

Answer 18

No, non-tender

Question 19

This is the most common cancer in men
Typical age >50

Answer 19

Prostatic adenocarcinoma

Question 20

Most Prostatic adenocarcinoma arise in this zone

Answer 20

Posterior peripheral zone

Question 21

Prostatic adenocarcinoma release this antigen

Answer 21

Prostate specific antigen (PSA)

Question 22

These are the 2 most frequent metastatic sites of Prostatic adenocarcinoma

Answer 22

Retroperitoneal lymph nodes
Vertebral column (and other bones)

Question 23

This can be used to screen for Prostatic adenocarcinoma
Is tissue specific, but not tumor specific

Answer 23

Prostate specific antigen (PSA)

Question 24

Prostate specific antigen (PSA) higher than this is concerning

Answer 24

> 10

Question 25

Prostate specific antigen (PSA) is most useful for this

Answer 25

Monitor for Prostatic adenocarcinoma recurrence after prostatectomy

Question 26

A patient with this may have an asymmetric, firm, fixed, usually advanced if palpable Bone pain, hypercalcemia

Answer 26

Prostatic adenocarcinoma

Question 27

Does a normal prostate histology have nucleoli?

Answer 27

No

Question 28

Describe the glands in Prostatic adenocarcinoma

Answer 28

Small glands No basal cells Large nucleoli

Question 29

This is the scoring system for prostate cancer

Answer 29

Gleason grading

Question 30

Gleason grade of this tends to be indolent

Answer 30

3+3=6

Question 31

Any gleason pattern of this is aggressive Favor surgical treatment

Answer 31

4

Question 32

Gleason patter of this indicates more metastases at diagnosis Surgery less successful

Answer 32

5

Question 33

Prostatic adenocarcinoma invades these lymph nodes

Answer 33

Iliac, para-aortic

Question 34

Prostatic adenocarcinoma distant metastasis favors this

Answer 34

Bone (often osteoblastic)

Question 35

This is the precursor lesion to Prostatic adenocarcinoma

Answer 35

High grade prostatic intraepithelial neoplasia

Question 36

This prostatic condition histology shows papillary or undulating often Nucleoli Retained basal cells

Answer 36

High grade prostatic intraepithelial neoplasia

Question 37

This is an androgen controlled promoter seen in Prostatic adenocarcinoma

Answer 37

TMPRSS2

Question 38

This is an oncogene seen in Prostatic adenocarcinoma

Answer 38

ETC