Protein Sorting (Membrane Proteins)

Question 1

GPI (glycosylphosphatidylinositol) what the ?

Answer 1

“GPI” are added to proteins destined for the membrane, they have these GPI anchors added to their carboxyl end

Question 2

Where would you find a “folding sensor” and what does it do?

Answer 2

in the ER: it filters out incorrectly folded proteins

Question 3

Celreticulin

Answer 3

a chaperone protein involved in helping translocate misfolded proteins around

Question 4

translocon

Answer 4

membrane channel

Question 5

Flippase: what am I and where am I

Answer 5

transferace involved in chaperoning newly synthesized phosopholipids to the luminal leaflet of the ER