Proteins
Diverse group of biological macromolecules
Proteins (7 functions)
What are proteins made up?
20 different amino acids
o R Group
• Nonpolar amino acids o Leucine -CH2 and -CH3 • Polar uncharged amino acids o Threonine Oxygen (-OH) • Charge amino acids o Glutamic acid Acids or bases that can ionize • Aromatic amino acids o Phenylalanine Organic (carbon) ring
o Peptide bond
Covalent bond that links two amino acids
o Polypeptide
Amino acids linked by peptide bonds
What determines protein function?
Shape
o Amino acid sequence
o Only portion of proteins that form hydrogen bonds o Polypeptide backbone o Regions of protein Cylindrical (a helices) Planer (B sheets
o Denatured
Fully unfolded
o Two or more polypeptide chains
o Motifs
Similar structures
Like a word compared to letters
o Domains
Functional units within a larger structure
Substructure within tertiary structure of a protein
Chaperone Proteins
o Help other proteins to fold correctly