Prototypes + class

Question 1

class of chemo drugs that target S phase of cell cycle

Answer 1

◦ Antimetabolites

Question 2

Class of chemo drugs that target G2 phase of cell cycle?

Answer 2

taxanes/taxoids

Question 3

Class of chemo drugs that target M phase of cell cycle?

Answer 3

◦ Vinca alkaloids

Question 4

Chemo drugs that have killing action REGARDLESS of cell cycle phase?

Answer 4

◦ Alkylating agents

◦ Antitumor antibodies

Question 5

4 types of cytotoxic agents

Answer 5

a) Alkylating Agents
b) Antimetabolites
c) Antitumor antibiotics
d) Mitotic Inhibitors

Question 6

prototype for hormone/hormone antagonist chemotherapy

Answer 6

tamoxifen (Nolvadex) –> SERM

Question 7

2 classes of targeted therapies for cancer (nommy little bits)

Answer 7

nibs and mabs

Question 8

2 types of biological response modifiers?

Answer 8

1. immunostimmulants: interlukin and interferons

2. immunosuppressant

Question 9

2 types of immunostimulants

Answer 9

interleukins

interferons

Question 10

Classes of drugs to treat PUD (5)

Answer 10

• Antibiotics for H.Pylori
• Anti Secretory
• Mucosal Protectant
• Prostaglandin Agent
• Antacid

Question 11

3 types of anti secretory agents:

Answer 11

• H2Blockers
• Proton Pump Inhibitors
• Muscarinic antagonist ??? (she never really talked about these but listed it. lmk if I missed a beat on this)

Question 12

prototype of H2 blockers

Answer 12

• Prototype: cimetidine (Tagamet) –> in the drug book, original H2 blocker
• Also Know: famotidine (Pepcid) –> more commonly used

Question 13

prototype for anti secretory: proton pump inhibitor

Answer 13

omeprazole (Prilosec)

Question 14

prototype for mucosal protectant

Answer 14

Sucralfate

Question 15

Prostaglandin Agent prototype

Answer 15

misoprostol (Cytotec)

Question 16

different kinds of antacid compounds (elements)

Answer 16

aluminum
magnesium
calcium
sodium

Question 17

prototype for Serotonin Receptor Antagonists

Answer 17

ondansetron (Zofran)

Question 18

prototype for Substance P Neurokinin1Antagonists

Answer 18

aprepitant (Emend)

Question 19

prototype for Glucocorticoids

Answer 19

dexamethasone (Decadron)

Question 20

prototype for Benzodiazepines for nausea

Answer 20

lorazepam (Ativan)

Question 21

prototype for phenothiazines

Answer 21

Promethazine (Phenergan)

Question 22

prototype for cannabinoids

Answer 22

dronabinol (Marinol)

Question 23

prototype for Anticholinergics/ Antihistamines for nausea

Answer 23

hydroxyzine (Vistaril)

Question 24

prototype for 5-Aminosalicylates

Answer 24

Sulfasalazine

Question 25

prototype for targeted therapy for IBD

Answer 25

Monoclonal antibodies : infliximab (Remicade)

Question 26

Antibiotics for Crohn's

Answer 26

• Metronidazole (Flagyl) AND Ciprofloxacin (Cipro) **nopt for UC

Question 27

prototype for bulk forming laxative

Answer 27

Psyllium (Metamucil)

Question 28

prototype for Surfactant Laxatives

Answer 28

docusate sodium (Colace)

Question 29

prototype for osmotic laxatives

Answer 29

polyethylene glycol (Miralax)

Question 30

lubiprostone (Amitiza) falls in what class of laxative?

Answer 30

misc!

Question 31

prototype for short duration RAPID acting insulin?

Answer 31

Aspart (novolog) | I want to get through the ass part very quickly

Question 32

prototype for SLOWER acting insulin?

Answer 32

RegulAR (Humulin R, Novolin R) | slowAR regulAR R R R R

Question 33

prototype for intermediate acting insulin?

Answer 33

Intermediate acting NPH (Humulin N, Novolin N) | iNtermediate Nph humulin N N N N N

Question 34

prototype for long acting insulin?

Answer 34

glargine (Lantus) (U-100) | Long Acting - LAntus, gLArgine

Question 35

prototype for Ultra-long duration Insulin

Answer 35

Insulin glargine (U-300) (Toujeo)

Question 36

prototype for combination insulin

Answer 36

NPH/regular 70/30 (Humulin 70/30)

Question 37

prototype for biguanides

Answer 37

metformin (Glucophage)

Question 38

prototype for sulfonylureas?

Answer 38

glipizide (Glucotrol XL)

Question 39

prototype for Glinides (Meglitinides)

Answer 39

repaglinide (Prandin)

Question 40

prototype for Thiazolidinediones (TZD) or “glitazones”

Answer 40

pioglitazone (Actos)

Question 41

prototype for Alpha-glucosidase Inhibitors

Answer 41

acarbose (Precose)

Question 42

prototype for SGLT-2 Inhibitors

Answer 42

canagliflozin (Invokana)

Question 43

prototype for GLP-1 Receptor Agonist/Mimetics

Answer 43

Exanatide (Byetta)

Question 44

prototype for DPP-4 Inhibitors?

Answer 44

: “gliptins” ----> Sitagliptin (Januvia)

Question 45

prototype for Amylin Mimetics

Answer 45

Pramlintide (Symlin)