CYP inhibitors
Grapefruit
Omeprazole
Disulfiram
Ethanol (chronic)
Valporate
Isoniazid
Carbamazepine
Erythromycin
Sulphonamides (abx)
CYP inducers
Phenytoin
Carbamazepine
Barbiturates (phenobarbital)
Rifampicin
Alcohol (chronic)
Sulphonylureas (gliclazide)
fluid prescription for child
100ml/kg for 0-10
50ml/kg for 10-20
20ml/kg for 20+
how much glucose in 1l of 5% dex
50g
how much K+ in 0.15% and 0.3%?
0.15% has 20 mmol
0.3% has 40 mmol
when would you choose amitriptyline
neuropathic pain (will be chronic), chronic, tension headache
when would you choose gabapentin?
diabetic neuropathy
as a muscle relaxant
when would you choose ibuprofen (or NSAIDs)
MSK pain
what drugs commonly give dyspepsia
nsaids
steroids
bisphosphonates
CCBs
Antimuscarinics
drugs that reduce kidney function
-ACEi, ARB, diuretics
-NSAIDs
-Aminoglycosides (gentamicin, tobramycin), Vancomycin, trimethoprim
-Contrast agents for CT
-Calcineurin inhibitors (ciclosporin, tacrolimus), methotrexate
-Lithium
-Acyclovir, tenofovir
-Zoledronic Acid / bisphosphonates
drugs that cause confusion
Opiates
Benzodiazepines
z-drugs
anticholinergics
antipsychotics
anticonvulsants
parkinson’s medications
digoxin toxicity
alcohol
hyponatraemia
drugs that cause hyponatraemia
Thiazides, thiazide like & loop diuretics
SSRIs, SNRIs, TCAs
Antiepileptics (carbamazepine, valproate)
Antipsychotics (haloperidol, risperidone, olanzapine, quetiapine)
ACEi, ARB
NSAIDs
PPI
drugs that cause glucose intolerance
Thiazides
Steroids
Antipsychotics
Calcineurin inhibitors (ciclosporin, tacrolimus)
Beta blockers
drugs that cause urinary retention
TCAs
Anticholinergics
Opioids
NSAIDs
anaesthetic agents
drugs that cause lung fibrosis
Amiodarone
Methotrexate, sulfasalazine
Nitrofurantoin
drugs that cause prolonged QTc interval
MATH FAN
-Macrolides (Clarithromycin, Erythromycin)
-Anti-arrhythmics (Amiodarone, Quinine, Sotalol)
-Tricyclic antidepressants (Amitriptyline)
-Histamine antagonists (Ranitidine, Cimetidine)
-Fluroquinolones (Ciprofloxacin, Levofloxacin)
-Antidepressants (Sertraline, Citalopram, Venlafaxine)
-Neuroleptics (Haloperidol, Clozapine)
drugs that cause hyperkalaemia
ACEi, ARB
Mineralocorticoid receptor antagonists (spironolactone)
Potassium-sparing diuretics (spironolactone, amiloride)
NSAIDs
Non-selective beta-adrenoceptor blockers (atenolol, propranolol)
Trimethoprim
drugs that lower seizure threshold
At high doses only:
Beta-lactams
Lidocaine
Antidepressants (except TCAs)
Isoniazid
Antimalarials (not doxycycline)
Opioids
NSAIDs
Clozapine, olanzapine, haloperidol
TCAs
Theophylline
Amphetamines
Illicit drugs
drugs that cause ankle swelling
CCBs, α1-blockers, α2-adrenoreceptor agonists, β-blockers
Opioids
Calcineurin inhibitors
PPIs
Antipsychotics 2nd gen
Escitalopram, mirtazapine, venlafaxine
Carbamazepine, valporate
drugs that precipitate c. diff
Clindamycin
Cephalosporins (cef-, ceftriaxone, cefalexin)
Ciprofloxacin
Co-amoxiclav
PPIs
Low Mg and Na
drugs that cause ototoxicity
Gentamicin
Bumetanide
Furosemide- vestibular nerve worse affected in oral
Vancomycin
drugs that cause serotonin syndrome
SSRIs
SNRIs
TCAs
Opioids
Parkinson’s Treatment
Stimulants (amphetamines, methylphenidate)
Lithium
Vortioxetine
antimuscarinics
counteract parasympathetic rest & digest
oxybutinin
ipatropium
atropine
side effects
dry mouth, constipation, urine retention
alpha 1 blockers
dilate blood vessels
doxazosin
postural hypotension, epistaxis, oedema
