psoriasis

Question 1

median age of onset of psoriasis

Answer 1

20-30

Question 2

Psoriasis triggers (8)

Answer 2

1. environmental
2. stress
3. infection
4. excessive body weight
5. cigarette smoking
6. medications
7. excessive alcohol intake
8. weather/climate

Question 3

Medications that trigger induction or exacerbate psoriasis

Answer 3

1. beta blockers
2. lithium
3. antimalarials (plaquenil)
4. interferons
5. terbinafine
6. TNF’s
7. topical imiquimod
8. bupropion
9. VEGF antagonists
10. rituximab

Question 4

3 factors in pathogenesis of psoriasis

Answer 4

1. abnormal hyperproliferation and differentiation leading to epidermal hyperplasia
2. dermal infiltration by various immune cells
3. increase capillary permeability to the dermis

Question 5

What symptom of scalp psoriasis is most important in determining severity?

Answer 5

itch

Question 6

Signs of nail psoriasis (7)

Answer 6

1. nail pitting
2. oil spots
3. dystrophy
4. crumbling
5. onycholysis
6. yellowing
7. thickening

Question 7

Comorbidities associated with plaque psoriasis (7)

Answer 7

1. psoriatic arthritis
2. CV disease
3. metabolic syndrome (obesity, HTN, dyslipidemia, insulin resistance)
4. IBD
5. Ocular manifestations
6. Mental health (depression)
7. Substance abuse

Question 8

Histology of psoriasis